Maleic acid-induced inhibition of amino acid transport in rat kidney
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چکیده
منابع مشابه
Competitive inhibition of dibasic amino acid transport in rat kidney.
It has long been postulated that the dibasic amino acids, lysine, arginine, ornithine, and cystine, share a common renal tubular transport mechanism. This hypothesis has developed from two separate but related lines of evidence. The canine and human renal clearance studies of Pitts, Webber, and Brown (1, 2), Wright et al. (3), Beyer et al. (4), Kamin and Handler (5), and Robson and Rose (6) all...
متن کاملMaleic acid-induced proximal tubulopathy: Na:K pump inhibition.
Maleic acid (MA) administration to experimental animals induces a rapid, reversible, complex dysfunction of the renal tubule resembling Fanconi's syndrome. The intent of this work was to characterize the changes in the Na:K pump along the nephron during the development and recovery from MA injury to better define the site of damage and to correlate the observed changes in Na:K pump function wit...
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Intestinal endocrine cells release gut hormones, including glucagon-like peptides (GLPs), in response to luminal nutrients. Luminal L-glutamate (L-Glu) and 5'-inosine monophosphate (IMP) synergistically increases duodenal HCO3- secretion via GLP-2 release. Since L cells express the bile acid receptor TGR5 and dipeptidyl peptidase (DPP) IV rapidly degrades GLPs, we hypothesized that luminal amin...
متن کاملAmino Acid Transport in Kidney HETEROGENEITY OF a-AMINOISOBUTYRIC UPTAKE*
1. More than one mode of transport can be observed for concentrative uptake of a-aminoisobutyric acid (AIB) by rat kidney cortex slices when the initial concentration of AIB in the medium is varied between 0.2 and 16 mM. 2. The relative contribution from both systems to the total observed uptake at various concentrations of AIB was calculated. The K, values for the two systems were 3.87 rnM and...
متن کاملAmino acid transport in kidney. Heterogeneity of alpha-aminoisobutyric uptake.
1. More than one mode of transport can be observed for concentrative uptake of a-aminoisobutyric acid (AIB) by rat kidney cortex slices when the initial concentration of AIB in the medium is varied between 0.2 and 16 mM. 2. The relative contribution from both systems to the total observed uptake at various concentrations of AIB was calculated. The K, values for the two systems were 3.87 rnM and...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1964
ISSN: 0006-2936
DOI: 10.1042/bj0920345